English Voice Cast
- Vash the Stampede - Johnny Yong Bosch
- Gasback Gallon Getaway - John Swasey
- Amelia Ann McFly - Colleen Clinkenbeard
- Meryl Stryfe - Luci Christian
- Nicholas D. Wolfwood - Brad Hawkins
- Milly Thompson - Trina Nishimura
- Caine Flaccano/Kepler - Kent Williams
- Shane B. Goodman - Robert McCollum
- Dorino Ohre Tadiski - Sonny Strait
- Mechio Tante Ogorare - Newton Pittman
- Amelia's Mother - Lydia Mackay
- Young Amelia - Cherami Leigh
Additional Voices
- Chuck Huber - Long-Haired Thug
- Scott Freeman
- Andrew Love - Black Thug
- Phil Parsons
- Todd Haberkorn - Spiky Purple-Haired Man
- Micah Solusod
- Duncan Brannan
- Mark Stoddard - Bank Manager
- Wendy Powell - Market Saleswoman
- Luci Christian
- Vic Mignogna - Blue-Shirted Ladies Man
- Lindsay Seidel
- Tyson Rinehart
- Leah Clark
- Tyler Walker
- Kenny Green
- Steve Powell
- Justin Pate
- Sean Michael Teague
- Josh Grelle - Gossiping Man B
- Scott Porter
- Jonathan Brooks - Concerned Man A
- Ryan Manalansan
- Jerry Russell
- Jerome 57
- J. Michael Tatum - Gossiping Man A
- Ben Phillips
- Greg Silva
- Anthony Bowling
- Eric Vale - Bank Security Guard
- Robert Bell
- Ed Blaylock
- Chris Rager
- Duane Deering
- Chris Cason
- Douglass Burks
- Charlie Campbell
- David Trosko
- Jamie Marchi - Woman with Children
- Cynthia Cranz
- Charles Baker
- Cris George
- Corey Cleary-Stoner
- Craig Dvorak
- Bryan Massey
- Clifton Hall
- Brina Palencia - Boy
- Christopher Bevins
- Jeremy Inman
- Anastasia Munoz
- Jason Grundy
- Christopher R. Sabat
Uncredited
- R Bruce Elliott - Old Man, Sheriff
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